Myasthenia Gravis Info

Wat is Myasthenia Gravis

Wikipedia - Myasthenia Gravis
Myasthenia gravis (Latijn voor 'ernstige spierzwakte'), ook wel kortweg MG is een zeldzame auto-immuunziekte, die gekenmerkt wordt door ernstige spierzwakte. Myasthenia gravis wordt veroorzaakt doordat auto-antilichamen de acetylcholinereceptoren op de motorische eindplaat binden waardoor deze worden afgebroken. Het gevolg hiervan is dat de signaaloverdracht van de zenuw naar de spier verhinderd wordt, waardoor de spier verzwakt.

Wikipedia - Myasthenia Gravis
The hallmark of myasthenia gravis is muscle weakness that increases during periods of activity and improves after periods of rest. Muscles that control eye and eyelid movement, facial expression, chewing, talking, and swallowing are especially susceptible. The muscles that control breathing and neck and limb movements can also be affected. Often the physical examination is within normal limits. The onset of the disorder can be sudden or rapid. Often symptoms come and go over time. The diagnosis of myasthenia gravis may be delayed if the symptoms are subtle or variable.

Wikipedia - Myasthenia Gravis
TDie Myasthenia gravis (M. g., deutsch: schwere Muskelschwäche) ist eine seltene neurologische Erkrankung, deren charakteristisches Kennzeichen eine belastungsabhängige Muskelschwäche ist, die sich in Ruhe wieder bessert. Sie macht sich durch eine schnelle Ermüdbarkeit bei wiederholten Bewegungen bemerkbar. Es handelt sich um eine Autoimmunerkrankung der motorischen Endplatte der quergestreiften Muskulatur. Polyklonale IgG-Antikörper binden an den Acetylcholinrezeptor und blockieren die Weiterleitung des Aktionspotenzials auf die Muskelzelle.

Diagnose me - Myasthenia Gravis
The first noticeable symptoms of myasthenia gravis may be weakness of the eye muscles, difficulty in swallowing, or slurred speech. Symptoms vary in type and severity. The onset of the disease involves only eye symptoms in 40% of patients, is generalized in 40%, and affects only the extremities in 10% (muscles close to joints are more severely affected than those further away). As the disease progresses, the weakness often spreads over the entire body. After the first year with myasthenia gravis, almost all patients have eye involvement, and in cases where the disease is destined to become generalized 90% will have become so involved. In 16% of patients only the eyes will ever be involved. During the first three years the progression of the disease is rapid and most deaths occur during this time. Myasthenia gravis occurs at all ages, usually between the ages of 20 and 40. If thymoma is associated, older men are more commonly affected.
Myasthenia gravis bij kinderen
Informatie over de diagnose en behandeling bij kinderen.